Publications
Dooling, L.J.*; Andrechak, J.C.*; Hayes, B.H.; Kadu, S.; Zhang, W.; Pan, R.; Vashisth, M.; Irianto, J.; Alvey, C.M.; Ma, L.; Discher, D.E. Cooperative phagocytosis underlies macrophage immunotherapy of solid tumours and initiates a broad anti-tumour IgG response. Nature Biomedical Engineering 2023.
Dooling, L.J.; Saini, K.; Anlaş, A.A.; Discher, D.E. Tissue mechanics coevolves with fibrillar matrisomes in healthy and fibrotic tissues. Matrix Biology. 2022. 111, 153-188
Andrechak, J.C.*; Dooling, L.J.*; Discher, D.E. Recognition of ‘self’ cells by macrophages: from clinical trials of blocking antibodies to mechanobiological fundamentals. Philosophical Transactions of the Royal Society B. 2019. 374. 20180217.
Dooling, L.J.; Discher, D.E. Inhibiting tumor fibrosis and actomyosin through GPCR activation. Trends in Cancer. 2019. 5. 197-199.
Dooling, L.J.; Tirrell, D.A. Engineering the dynamics of protein hydrogel networks through sequence variation. ACS Central Science. 2016. 2. 812-819.
Dooling, L.J.; Buck, M.E.; Zhang, W.-B.; Tirrell, D.A. Programming molecular association and viscoelastic behavior in protein networks. Advanced Materials. 2016. 28 4651-4657.
Dooling, L.J.; Tirrell, D.A. Peptide and Protein Hydrogels. In Polymeric and Self Assembled Hydrogels: From Fundamental Understanding to Applications. Loh, X.J.; Scherman, O.A., Eds.; RSC Publishing: Cambridge, U.K., 2013; p 93.
Hayes, B.H.; Wang, M.; Zhu, H.; Phan, S.; Dooling, L.J.; Andrechak, J.C.; Chang, A.H.; Tobin, M.P.; Ontko, N.M.; Marchena, T; Discher, D.E. Chromosomal instability can favor macrophage-mediated immune response and induce a broad, vaccination-like anti-tumor IgG response. eLife. 2024. 12. RP88054.
Usman, O.H.; Kumar, S, Walker III, R.R; Xie, G.; Jalil, A.A.R.; Dooling, L.J.; Wang, Y.J.; Irianto, J. Differential roles of extracellular matrix proteins on primary and metastatic pancreatic cancer cell. Molecular Biology of the Cell 2023. 34(13) ar130.
Hayes, B.H.; Zhu, H.; Andrechak, J.C.; Dooling, L.J.; Discher D.E. Titrating CD47 by mismatch CRISPRi reveals incomplete repression can eliminate IgG-opsonized tumors but limits induction of anti-tumor IgG. PNAS Nexus 2023. 2(8) pgad243.
Ivanovska, I.L.; Tobin, M.P.; Bai, T.; Dooling, L.J.; Discher, D.E. Small fat droplets are sufficiently rigid to indent a nucleus, dilute the lamina, and cause rupture. Journal of Cell Biology. 2023. 222 (8) e202208123.
Hayes, B.H.; Zhu, P.K.; Wang, M.; Pfeifer, C.R.; Xia, Y.; Phan, S.; Andrechak, J.C.; Du, J.; Tobin, M.P.; Anlaş, A.; Dooling, L.J.; Vashisth, M.; Irianto, J.; Lampson, M.A.; Discher, D.E. Confinement with Myosin-II suppression increases heritable loss of chromosomes, using live-cell ChReporters. Journal of Cell Science 2023. 136 (11).
Andrechak, J.C.; Dooling, L.J.; Tobin, M.P.; Zhang, W.; Hayes, B.H.; Lee, J.Y.; Jin, X.; Irianto, J.; Discher, D.E. CD47-SIRPα immune checkpoint blockade of metastatic lung melanoma requires a tumor-targeting antibody to suppress tumor growth. Cancers. 2022 14, 1930.
Pfeifer, C.R.; Tobin, M.P.; Cho, S.; Vashisth, M.; Dooling, L.J.; Lopez Vazquez, L.; Ricci-De Lucca, E.G.; Simon, K.T.; Discher, D.E. Gaussian curvature dilutes the nuclear lamina, favoring nuclear rupture, especially at high strain rate. Nucleus 2022 13 (1), 129-143.
Hayes, B.H.; Tsai, R.K.; Dooling, L.J.; Kadu, S.; Lee, J.Y.; Pantano, D.; Rodriguez, P.L.; Subramanian, S.; Shin, J.-W.; Discher, D.E. Macrophages show higher levels of engulfment after disruption of cis interactions between CD47 and the checkpoint receptor SIRPα. Journal of Cell Science. 2020. 133.
Saini, K.; Cho, S.; Dooling, L.J.; Discher, D.E. Tension in fibrils suppresses their enzymatic degradation – A molecular mechanism for ‘use it or lose it’. Matrix Biology 2020. 85. 34-46.
Xia, Y.; Pfeifer, C.R.; Zhu, K; Irianto, J.; Liu, D.; Pannell, K.; Chen, E.; Dooling, L.J.; Tobin, M.P.; Wang, M.; Ivanovska, I.L.; Smith, L.R.; Greenberg, R.A.; Discher, D.E. Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle. Journal of Cell Biology. 2019. 218. 2545-2563.
Devari, D.; Pfeifer, C.R.; Dooling, L.J.; Ivanovska, I.L.; Discher, D.E.; Safran, S.A. Scaling laws indicate distinct nucleation mechanisms of holes in the nuclear lamina. Nature Physics. 2019. 15. 823-829.
Discher, D.E.; Dooling, L.J. Optimal contractile forces for a mesenchymal engine. Developmental Cell. 2017. 42. 313-315.
Kim, J.-H.; Dooling, L.J.; Asthagiri, A.R. Intercellular mechanotransduction during multicellular morphodynamics. Journal of The Royal Society Interface 2010, 7 S341-S350.